trial sequential analysis tsa (STATA Corporation)
Structured Review

Trial Sequential Analysis Tsa, supplied by STATA Corporation, used in various techniques. Bioz Stars score: 99/100, based on 36112 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/trial+sequential+analysis+tsa/pmc10746851-132-15-20?v=STATA+Corporation
Average 99 stars, based on 36112 article reviews
Images
1) Product Images from "Efficacy and safety of anti-CD38 monoclonal antibodies in patients with relapsed/refractory multiple myeloma: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials"
Article Title: Efficacy and safety of anti-CD38 monoclonal antibodies in patients with relapsed/refractory multiple myeloma: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials
Journal: Frontiers in Oncology
doi: 10.3389/fonc.2023.1240318
Figure Legend Snippet: Trial sequential analysis (TSA) of progression-free survival (PFS) and overall survival (OS) after anti-CD38 mAbs therapy for RRMM. (A) PFS; (B) OS. Red inward-sloping line to the left represents trial sequential monitoring boundary. Blue line represents evolution of cumulative Z-score. Horizontal green lines represent the conventional boundaries for statistical significance. Heterogeneity-adjusted required information size to demonstrate or reject 15% relative risk ( a priori estimate) of mortality risk (with alpha of 5% and beta of 20%) is 2388 patients for PFS and 2653 patients for OS (vertical red line). Cumulative Z-curve crossing the trial sequential monitoring boundary or the APIS boundary provides firm evidence of effect.
Techniques Used: